When is the best time to take doxycycline?

The best time to take doxycycline depends on your dosage schedule and the condition being treated, but here are the general guidelines based on expert sources2:

🕒 Best Time to Take Doxycycline

Take it on an empty stomach: Ideally 1 hour before or 2 hours after meals for better absorption.

Avoid taking it right before bed: To prevent throat irritation or esophageal ulcers, take it at least 1 hour before lying down.

If taken twice daily: Space doses 12 hours apart, such as morning and evening.

💧 How to Take It

Take with a full glass of water while sitting or standing upright.

Avoid lying down for at least 30 minutes after taking it.

You may take it with food if it causes stomach upset, though this may slightly reduce absorption.

⚠️ Avoid Taking With

Dairy products, antacids, iron, or calcium supplements within 2 hours of your dose, as they can interfere with absorption.