A fig of radical are believed to person died successful a motorway clang involving 2 lorries and respective cars, constabulary person said.
Durham Police said the vehicles collided portion travelling northbound connected the A1(M) betwixt Bradbury and Carrville, astatine astir 18:20 BST.
The motorway has been closed successful some directions.
Appealing for accusation astir the crash, a constabulary spokesperson said determination "appear to person been fatalities".
The North East Ambulance work said it was "incredibly busy" dealing with the crash, which it warned could pb to delays to it attending different emergencies successful the area.
The motorway is expected to stay unopen for a fig of hours and motorists are being advised to debar the area.
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